Types of Hallucinogens

Impacts the brain by acting on serotonin receptors (5-HT receptors), leading to increased neural activity and altered connectivity. These changes result in the characteristic hallucinogenic effects, altered perceptions, and emotional experiences. While the drug can induce positive and potentially therapeutic experiences, it also carries risks, particularly for individuals predisposed to mental health disorders.

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HOW LONG DOES LSD LAST?

• Total: 8 - 12 hours

• Onset: 15 - 30 minutes

• Come up: 45 - 90 minutes

• Peak: 3 - 5 hours

• Offset: 3 - 5 hours

• After effects: 12 - 48 hours

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DOSAGES

• Threshold: 15 µg

• Light: 25 - 75 µg

• Common: 75 - 150 µg

• Strong: 150 - 300 µg

• Heavy: 300 µg +

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EFFECTS SPECIFIC TO LSD

• EXTENDED DURATION: LSD has a much longer duration of action than other psychedelics.  Effects can last 8-12 hours, or possibly more, while other drugs such as DMT and psilocybin have much shorter durations (4-6 hours for psilocybin, minutes for DMT​

• HIGHLY DETAILED VISUAL HALLUCINATIONS: visual hallucinations induced by LSD are often reported to be more detailed, intricate, and geometric compared to those from other psychedelics. Users frequently describe complex fractals, vibrant colors, and continuously morphing patterns.​

• INTELLECTUAL INSIGHTS: LSD is known for inducing profound cognitive shifts, leading to deep introspective thoughts and intellectual insights. Users often report a heightened sense of understanding and the ability to connect seemingly unrelated ideas.​

• EGO DISSOLUTION: While other psychedelics can also induce ego dissolution, the experience on LSD is often described as more gradual and controlled, allowing users to explore and navigate this state more consciously.​

• BROADER RECEPTOR ACTIVATION: While LSD primarily affects the 5-HT2A receptor like all psychedelics, it also has activity at other serotonin receptors, dopamine receptors, and even some adrenergic receptors, contributing to its unique profile of effects.

• ​DISTORTED SENSE OF TIME: The distortion of time perception on LSD is often more intense, with users feeling like time is stretching, looping, or standing still. This effect can be more pronounced than with other psychedelics.

• ​SPATIAL DISTORTIONS: LSD can cause significant alterations in spatial perception, making objects appear to move, breathe, or warp in a way that feels unique to the LSD experience.

Dimethyltryptamine (DMT) is a powerful psychedelic compound that has significant effects on the brain.  DMT not only binds to 5-HT2A receptors but also has affinity for other receptor types, such as the sigma-1 receptor. The sigma-1 receptor is involved in neuroprotection and modulation of the immune response, and its activation by DMT might contribute to the compound's unique subjective effects and potential therapeutic benefits, differentiating it from other classical psychedelics.

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HOW LONG DOES DMT LAST?

Total: 6-20 mins

Onset: 0-1 mins

Come up: 0-30 secs

Peak: 3-15 mins

Offset: 3-5 mins

After effects: 15-60 mins

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DOSAGES

Threshold: 2-5 mg

Light: 10-20 mg

Common: 20-40 mg

Strong: 40-60 mg

Heavy: 60 mg +

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EFFECTS SPECIFIC TO DMT

• INTENSE VISUAL HALLUCINATIONS: DMT is renowned for its vivid, complex, and often geometric visual hallucinations, which can be more intense than those of other psychedelics.

• RAPID ONSET AND SHORT DURATION: Unlike many other psychedelics, DMT's effects are almost immediate and brief, often described as a "breakthrough" experience.

• ALTERED SENSE OF REALITY: Users often report experiences of alternate realities or encounters with entity-like beings, which can feel profoundly real.

• MYSTICAL AND SPIRITUAL EXPERIENCES: DMT is often associated with mystical experiences, where users report feelings of unity, transcendence, and deep existential insight.

• EGO DISSOLUTION: Similar to other psychedelics, DMT can lead to a temporary loss of the sense of self, which can be both enlightening and disorienting.

• POTENTIAL FOR INTENSE EXPERIENCES: The intensity of a DMT experience can be overwhelming, making it crucial for users to approach with caution and in a safe setting.

Mescaline is a naturally occurring psychedelic alkaloid found in certain cacti, such as Peyote and San Pedro. It primarily affects the serotonin receptors, particularly 5-HT2A, leading to altered states of consciousness, enhanced sensory perceptions, and often spiritual or mystical experiences. 

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HOW LONG DOES MESCALINE LAST?

• Total: 8 - 14 hours

• Onset: 45 - 120 minutes

• Come up: 1 - 2 hours

• Peak: 4 - 6 hours

• Offset: 2 - 4 hours

• After effects: 24 hours (mild residual effects)

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DOSAGES:

• Threshold: 50 - 100 mg

• Light: 100 - 200 mg

• Common: 200 - 300 mg

• Strong: 300 - 500 mg

• Heavy: 500 mg +

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EFFECTS SPECIFIC TO MESCALINE

• ENHANCED SENSORY PERCEPTION: Users often report heightened sensory experiences, where colors appear more vivid, sounds are enriched, and textures are intensified.

• EMOTIONAL INSIGHT AND EMPATHY: Mescaline is known for fostering emotional openness and empathy, often leading to enhanced personal and interpersonal understanding.

• VISUAL HALLUCINATIONS: While visual effects are prominent, they are often less geometric than those of LSD, presenting as a more natural enhancement of the environment.

• SPIRITUAL AND MYSTICAL EXPERIENCES: Many users experience profound spiritual or mystical states, often feeling a deep connection with nature and the universe.

• TIME DILATION: Users commonly report a distorted sense of time, feeling as though time is slowing down or stretching out.

• PHYSICAL SENSATIONS: Mescaline can cause physical sensations such as a tingling body feeling or warmth, adding to the overall sensory experience.

2C-B is a synthetic psychedelic belonging to the phenethylamine class, known for its unique blend of hallucinogenic and entactogenic effects. It acts on serotonin receptors, particularly the 5-HT2A receptor, and is valued for its sensory enhancement and empathetic effects. It offers a relatively shorter duration of action compared to other psychedelics and is sometimes used in social or party settings. 

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HOW LONG DOES 2C-B LAST?

• Total: 4 - 8 hours

• Onset: 20 - 90 minutes

• Come up: 30 - 60 minutes

• Peak: 2 - 4 hours

• Offset: 1 - 2 hours

• After effects: 1 - 4 hours (some mild lingering sensations)

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DOSAGES:

• Threshold: 2 - 5 mg

• Light: 5 - 10 mg

• Common: 10 - 20 mg

• Strong: 20 - 30 mg

• Heavy: 30 mg +

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EFFECTS SPECIFIC TO 2C-B

• ENHANCED SENSORY PERCEPTION: 2C-B is known for intensifying visual, auditory, and tactile sensations, making colors appear more vivid and music more immersive.

• EMPATHOGENIC EFFECTS: Similar to MDMA, 2C-B can enhance feelings of empathy and emotional connection, often leading to a warm and sociable experience.

• VISUAL HALLUCINATIONS: Users often experience visual effects such as bright colors, geometric patterns, and mild distortions, which are generally more controllable compared to other psychedelics.

• MOOD LIFTING: The substance is known for its mood-enhancing properties, often inducing feelings of euphoria and well-being.

• MILD STIMULANT EFFECTS: 2C-B can cause a slight increase in energy and alertness without the intense physical stimulation associated with other stimulants.

• POTENTIAL FOR ANXIETY: Higher doses or sensitive individuals may experience anxiety or confusion, especially in unfamiliar or uncomfortable settings.

Psilocybin is converted to psilocin in the body, which like other psychedelics, acts on the serotonin (5-HT receptors), specifically the 5HT-2A receptors.  It also may encourage the brain to form new connections, potentially leading to lasting changes in behavior and mood. Psilocybin reduces activity in the DMN (Disrupts Default Mode Network), a brain network linked to self-reflective thinking. This can lead to ego dissolution, where the sense of self fades.

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HOW LONG DOES PSILOCYBIN LAST?

• Total: 4 - 6 hours

• Onset: 20 - 45 minutes

• Peak: 2 - 3 hours

• Offset: 1.5 - 2 hours

• After effects: 4 - 24 hours

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DOSAGES

• Threshold: 0.15 - 0.25 grams

• Light: 0.25 - 1 grams

• Common: 1 - 3 grams

• Strong: 3 - 6 grams

• Heavy: 6 grams +

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EFFECTS SPECIFIC TO PSILOCYBIN

• MODERATE DURATION: Psilocybin's effects typically last 4-6 hours, which is longer than DMT (minutes to an hour) but shorter than LSD (8-12 hours). This moderate duration can be more manageable for some users.

• NATURAL IMAGERY: Visual hallucinations from psilocybin often involve organic and nature-themed imagery, such as plants, animals, and landscapes. These visuals are typically less geometric and more fluid compared to the intricate patterns seen with LSD.

• EGO SOFTENING: While all classic psychedelics can cause ego dissolution, the experience with psilocybin is often described as a gentler "ego softening" rather than a complete dissolution, allowing for a more gradual and less overwhelming experience.

• INTROSPECTIVE THOUGH: Psilocybin is particularly noted for its ability to facilitate deep introspective thoughts and personal insights. Users often reflect on their lives, relationships, and personal issues with a new perspective.

• CLARITY AND RESOLUTION: The cognitive effects of psilocybin often lead to feelings of mental clarity and resolution, helping users to work through psychological issues and achieve personal breakthroughs.

Salvia Divinorum is a powerful psychoactive plant known for its strong and short-lived hallucinogenic effects. Unlike classical hallucinogens that primarily affect serotonin receptors, Salvia acts on kappa opioid receptors in the brain, leading to unique dissociative experiences and altered states of consciousness. 

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HOW LONG DOES SALVIA LAST?

• Total: 15 - 30 minutes

• Onset: 30 seconds - 2 minutes

• Come up: 1 - 2 minutes

• Peak: 5 - 10 minutes

• Offset: 5 - 15 minutes

• After effects: 15 - 30 minutes

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DOSAGES:

• Threshold: 50 - 100 µg

• Light: 100 - 200 µg

• Common: 200 - 500 µg

• Strong: 500 - 1000 µg

• Heavy: 1000 µg +

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EFFECTS SPECIFIC TO SALVIA

• INTENSE DISSOCIATION: Salvia is known for its dissociative effects, often causing users to feel detached from their body and surroundings. This can be more intense than the dissociation experienced with other psychedelics.

• ALTERED PERCEPTION OF REALITY: Users frequently report experiencing alternate realities or dream-like states that feel profoundly real yet disconnected from their everyday experience.

• UNIQUE PSYCHOLOGICAL INSIGHTS: While not universally positive, some users find the psychological insights gained from Salvia experiences to be unique, offering a different perspective on their consciousness and identity.

• RAPID ONSET AND SHORT DURATION: Unlike many other hallucinogens, Salvia acts very quickly and the experience is relatively short-lived, with effects dissipating within an hour.

• INTENSE VISUAL AND AUDITORY HALLUCINATIONS: Users often experience vivid visual and auditory hallucinations that are distinct from those produced by serotonergic hallucinogens.

• POTENTIAL FOR EMOTIONAL CHALLENGE: Due to its intensity and the nature of its effects, Salvia can be emotionally challenging, with some users reporting feelings of confusion or fear during the peak experience.

Ayahuasca is a traditional Amazonian brew made from the Banisteriopsis caapi vine and the leaves of the Psychotria viridis plant, containing the powerful psychedelic DMT. It is used in ceremonial settings for spiritual and therapeutic purposes. The brew acts on serotonin receptors, particularly 5-HT2A, and is known for its capacity to induce profound psychological and spiritual insights, emotional healing, and altered states of consciousness.

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HOW LONG DOES AYAHUASCA LAST?

• Total: 4 - 6 hours

• Onset: 20 - 60 minutes

• Come up: 1 - 2 hours

• Peak: 2 - 4 hours

• Offset: 1 - 2 hours

• After effects: Several hours to days (often described as an "afterglow" effect)

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DOSAGES

• Ayahuasca dosages vary widely due to differing potencies of the brew. It's typically measured in "cups" or similar servings, and dosage is often determined by an experienced facilitator in a ceremonial context.

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EFFECTS SPECIFIC TO AYAHUASCA

• DEEP EMOTIONAL RELEASE: Ayahuasca often leads to cathartic emotional experiences, helping users confront and process past traumas or deep-seated emotional issues.

• SPIRITUAL AND MYSTICAL EXPERIENCES: Users frequently report profound spiritual insights, a sense of connection to nature, and encounters with spiritual entities or guides.

• ENHANCED SELF-REFLECTION: The brew facilitates deep introspection and a greater understanding of one's life and existence, often leading to personal growth and insight.

• PHYSICAL REACTIONS: Ayahuasca is known for its purgative effects, often causing nausea, vomiting, or diarrhea, which are considered an integral part of the cleansing process.

• A SENSE OF UNITY AND INTERCONNECTEDNESS: Many users experience feelings of oneness with the universe and a deep connection with others and the environment.

• POTENTIAL FOR CHALLENGING EXPERIENCES: While many experiences are positive, Ayahuasca can also lead to challenging psychological experiences, requiring careful preparation and integration support.

Ibogaine is a naturally occurring psychoactive substance found in the root bark of the African shrub Tabernanthe iboga. It is primarily known for its use in treating addiction, particularly opioid dependence, due to its ability to reduce withdrawal symptoms and cravings. Ibogaine acts on multiple neurotransmitter systems, including serotonin, dopamine, and NMDA receptors, which contribute to its complex effects on consciousness and perception.

HOW LONG DOES IBOGAINE LAST?

• Total: 12 - 36 hours

• Onset: 1 - 3 hours

• Come up: 1 - 2 hours

• Peak: 4 - 8 hours

• Offset: 12 - 24 hours

• After effects: Several days to weeks (often described as a "reset" or afterglow effect)

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DOSAGES:

• Threshold: 50 - 100 mg

• Light: 100 - 300 mg

• Common: 300 - 500 mg

• Strong: 500 - 800 mg

• Heavy: 800 mg +

(Note: Dosage can vary widely based on individual factors and treatment context)

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EFFECTS SPECIFIC TO IBOGAINE

• INTENSE PSYCHOLOGICAL INSIGHT: Ibogaine is known for inducing deep introspection and can bring up vivid memories and emotions, often described as a "waking dream" or visionary state.

• POTENTIAL FOR ADDICTION INTERRUPTION: Many users report a significant reduction in cravings and withdrawal symptoms for substances like opioids and alcohol after an Ibogaine treatment session.

• SPIRITUAL AND MYSTICAL EXPERIENCES: Some users experience profound spiritual insights and a sense of connection to a higher power or the universe.

• PHYSICAL PURGATION: Ibogaine can cause nausea and vomiting, which some users interpret as a cleansing aspect of the experience.

• LONG-LASTING EFFECTS: Users often report a prolonged afterglow period characterized by mood stabilization and increased clarity, which can last for weeks or months.

• SIGNIFICANT RISKS: Ibogaine can pose serious health risks, including cardiac complications and psychological distress, making it crucial to use only under professional supervision.

professional supervision.